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Review
. 2009 Feb;10(2):129-32.
doi: 10.1038/ni0209-129.

Animal models of human type 1 diabetes

Matthias von Herrath  1 , Gerald T Nepom
Affiliations
Review

Animal models of human type 1 diabetes

Matthias von Herrath et al. Nat Immunol. 2009 Feb.

Abstract

Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta cells are damaged and destroyed. Animal models have served a prominent function in the development of the present ideas of pathogenesis and approaches to therapy. This commentary addresses the utility and limitations of these models for facilitating the 'translation' of immunology research into clinical applications.

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References

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