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. 2009 Jan 15;34(2):205-7.
doi: 10.1364/ol.34.000205.

Single-camera sequential-scan-based polarization-sensitive SDOCT for retinal imaging

Mingtao Zhao  1 , Joseph A Izatt
Affiliations

Single-camera sequential-scan-based polarization-sensitive SDOCT for retinal imaging

Mingtao Zhao et al. Opt Lett. .

Abstract

A single-camera, high-speed, polarization-sensitive, spectral-domain optical-coherence-tomography system was developed to measure the polarization properties of the in vivo human retina. A novel phase-unwrapping method in birefringent media is described to extract the total reflectivity, accumulative retardance, and fast-axis orientation from a specially designed sequence of polarization states incident on the sample. A quarter-wave plate was employed to test the performance of the system. The average error and standard deviation of retardation measurements were 3.2 degrees and 2.3 degrees , respectively, and of the fast-axis orientation 1.2 degrees and 0.7 degrees over the range of 0 degrees -180 degrees . The depolarization properties of the retinal pigment epithelium were clearly observed in both retardance and fast-axis orientation image. A normalized standard deviation of the retardance and of the fast-axis orientation is introduced to segment the polarization-scrambling layer of the retinal pigment epithelium.

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Figures

Fig. 1
Fig. 1
(Color online) Schematic of the PSOCT system: SP, spectrometer; PC, polarization controller; FC, fiber collimator; VP, vertical polarizer; M, mirror; BS, nonpolarization beam splitter.
Fig. 2
Fig. 2
(Color online) Quarter-wave-plate calibration: A, double pass phase retardance calibration. The mean absolute error was 3.2°, and the standard deviation was 2.3°; B, fast-axis orientation calibration. The mean absolute error was 1.2°, and the standard deviation was 0.7°.
Fig. 3
Fig. 3
(Color online) In vivo human retinal imaging results. A, reflectivity image; image size: ∼2.5 mm (x) ×2.5 mm (y), 500 lines. The unit of the gray color bar is decibels. Blue, light depolarization (65-70 db); green, middle depolarization (70-75 db); red, strong depolarization (>75 db). B, single-pass retardance; the depolarization scrambling RPE layer is viewed as a blue, green, and red interleaving band (bright white layer in black/white version). C, fast-axis orientation. D, the multiplication image of the standard deviation of retardance and the fast-axis orientation. The color bar is in units of decibels.
See this image and copyright information in PMC

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