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Case Reports
. 2008 Jul;11(2):152-5.

A case of atypical gastric carcinoma with osteoclast like giant cells

Rahul Pandit  1 , Irina A Danilova
Affiliations
Case Reports

A case of atypical gastric carcinoma with osteoclast like giant cells

Rahul Pandit et al. Mcgill J Med. 2008 Jul.

Abstract

Out of all the different types of neoplasms affecting the stomach, gastric carcinomas with Osteoclast-like Giant Cells (OGC) is one of the most uncommon. Although OGC are typically found in osseous neoplasms and tumors of the tendon sheath, few cases of extra-skeletal neoplasms with OGC have been documented. These typically involve organs such as the pancreas, gall-bladder, kidney, and breast. Even though the role of OGC in histogenesis of such tumors still remains unclear, their presence in extra-osseous neoplasms may indicate a certain level of immune reaction of the host towards the neoplastic transformation of normal tissue. We report a case of a 70-year-old Caucasian female hospitalized for evaluation of epigastric pain. Further examinations including endoscopy and biopsy of the stomach revealed gastric adenocarcinoma with OGC. This report also provides a brief insight into the possible immune reaction in such neoplasms.

Keywords: Osteoclast like Giant Cells (OGC); adeno-carcinoma.

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Figures

Figure 1
Figure 1
Moderately differentiated malignant glands with prominent lympho-histocytic infiltration of the stroma. Magnification 100X.
Figure 2
Figure 2
Arrow indicating stromal localization of a typical giant cell with multiple nuclei distributed circumferentially. Magnification 400X.
Figure 3
Figure 3
CD68 staining showing the positive staining of stromal elements with relatively free glands. Magnification 200X.
Figure 4
Figure 4
Positive staining of malignant glands for Pan-Cytokeratin antibodies . Magnification 200X.
See this image and copyright information in PMC

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