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. 2009;10(1):98-103.
doi: 10.1208/s12249-008-9182-1. Epub 2009 Jan 16.

Evaluation of polyethylene oxide compacts as gastroretentive delivery systems

Ravichandran Mahalingam  1 , Bhaskara Jasti, Raj Birudaraj, Dimitrios Stefanidis, Robert Killion, Tom Alfredson, Pratap Anne, Xiaoling Li
Affiliations

Evaluation of polyethylene oxide compacts as gastroretentive delivery systems

Ravichandran Mahalingam et al. AAPS PharmSciTech. 2009.

Abstract

Compacts containing selected bioadhesive polymers, fillers, and binders were investigated for their potential as a bioadhesive gastroretentive delivery system to deliver water soluble and water insoluble compounds in the stomach. Compacts with 90:10, 75:25, and 60:40 of polyvinylpyrrolidone (PVP) and polyethylene oxide (PEO) were evaluated for swelling, dissolution, bioadhesion, and in vitro gastric retention. Compacts containing higher PEO showed higher swelling (111.13%) and bioadhesion (0.62 +/- 0.03 N/cm(2)), and retained their integrity and adherence onto gastric mucosa for about 9 h under in vitro conditions. In vivo gastroretentive property of compacts were evaluated in Yorkshire cross swine. Compacts containing 58% PVP, 40% PEO and 2% of water soluble or water insoluble marker compounds showed gastroadhesive and retentive properties in vivo. It is concluded that PEO in combination with PVP yields a non disintegrating type bioadhesive dosage form which is suitable for gastroretentive applications.

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Figures

Fig. 1
Fig. 1
Bioadhesion testing setup
Fig. 2
Fig. 2
In vitro gastroretention study setup
Fig. 3
Fig. 3
Swelling of PEO-PVP compacts
Fig. 4
Fig. 4
Adhesion of MB compact in the body region of stomach after 1 h
Fig. 5
Fig. 5
Adhesion of PAA compact in the body region of stomach after 1 h
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References

    1. Ali J., Hasan S., Ali M. Formulation and development of gastroretentive drug delivery system for ofloxacin. Methods Find. Exp. Clin. Pharmacol. 2006;28(7):433–439. doi: 10.1358/mf.2006.28.7.1003574. - DOI - PubMed
    1. Ali J., et al. Development and evaluation of a gastroretentive drug delivery system for the low-absorption-window drug celecoxib. PDA J. Pharm. Sci. Technol. 2007;61(2):88–96. - PubMed
    1. Basak S. C., Rahman J., Ramalingam M. Design and in vitro testing of a floatable gastroretentive tablet of metformin hydrochloride. Pharmazie. 2007;62(2):145–148. - PubMed
    1. Christensen S. The biological fate of riboflavin in mammals. A survey of literature and own investigations. Acta Pharmacol. Toxicol. (Copenh). 1973;32:3–72. - PubMed
    1. Dave B. S., Amin A. F., Patel M. M. Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation. AAPS PharmSciTech. 2004;5(2):e34. doi: 10.1208/pt050234. - DOI - PMC - PubMed

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