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Review
. 2008 Nov;48(11):1549-55.

[Clustered regularly interspaced short palindromic repeats: structure, function and application--a review]

[Article in Chinese]
Affiliations
  • PMID: 19149174
Review

[Clustered regularly interspaced short palindromic repeats: structure, function and application--a review]

[Article in Chinese]
Yujun Cui et al. Wei Sheng Wu Xue Bao. 2008 Nov.

Abstract

CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats), the basis of spoligotyping technology, can provide prokaryotes with heritable adaptive immunity against phages' invasion. Studies on CRISPR loci and their associated elements, including various CAS (CRISPR-associated) proteins and leader sequences, are still in its infant period. We introduce the brief history', structure, function, bioinformatics research and application of this amazing immunity system in prokaryotic organism for inspiring more scientists to find their interest in this developing topic.

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