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Review
. 2009 Jan;10(1):38-41.
doi: 10.2174/138945009787122914.

PDGF-D signaling: a novel target in cancer therapy

Zhiwei Wang  1 , Dejuan Kong, Yiwei Li, Fazlul H Sarkar
Affiliations
Review

PDGF-D signaling: a novel target in cancer therapy

Zhiwei Wang et al. Curr Drug Targets. 2009 Jan.

Abstract

Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-beta. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.

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