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Case Reports
. 2009 Apr;24(4):477.
doi: 10.1177/0883073808324535. Epub 2009 Jan 16.

Rapamycin reduces seizure frequency in tuberous sclerosis complex

Jennifer Muncy  1 , Ian J Butler, Mary Kay Koenig
Affiliations
Case Reports

Rapamycin reduces seizure frequency in tuberous sclerosis complex

Jennifer Muncy et al. J Child Neurol. 2009 Apr.

Abstract

The authors present a 10-year-old girl with tuberous sclerosis complex who has been receiving rapamycin for 10 months for seizure control. She was started at 0.05 mg/kg/d and titrated to an effective dose of 0.15 mg/kg/d. There was a dramatic reduction in seizure frequency with rapamycin therapy. Further studies are needed to objectively investigate the benefits of rapamycin in tuberous sclerosis complex and to clarify its mechanism of seizure control.

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Conflict of interest statement

The authors have no conflicts of interest to disclose with regard to this article.

References

    1. Zeng LH, Xu L, Gutmann DH, Wong M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol. 2008;63:444–453. - PMC - PubMed

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