Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jan 28;15(4):385-406.
doi: 10.3748/wjg.15.385.

Intestinal hormones and growth factors: effects on the small intestine

Laurie Drozdowski, Alan B R Thomson
Review

Intestinal hormones and growth factors: effects on the small intestine

Laurie Drozdowski et al. World J Gastroenterol. .

Abstract

There are various hormones and growth factors which may modify the intestinal absorption of nutrients, and which might thereby be useful in a therapeutic setting, such as in persons with short bowel syndrome. In part I, we focus first on insulin-like growth factors, epidermal and transferring growth factors, thyroid hormones and glucocorticosteroids. Part II will detail the effects of glucagon-like peptide (GLP)-2 on intestinal absorption and adaptation, and the potential for an additive effect of GLP2 plus steroids.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Simplified model of GR-mediated transcriptional modulation. (from Bamberger et al 1996).
Figure 2
Figure 2
Post-translation processing of proglucagon in the pancreas and the intestinal L-cells. The numbers represent the amino acid at which enzymatic cleavage occurs.
See this image and copyright information in PMC

References

    1. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995;16:3–34. - PubMed
    1. Yang H, Ney DM. Insulin-like growth factor-I (IGF-I) responses in rats maintained with intravenous or intragastric infusion of total parenteral nutrition solutions containing medium- or long-chain triglyceride emulsions. Am J Clin Nutr. 1994;59:1403–1408. - PubMed
    1. Donovan SM, Hintz RL, Rosenfeld RG. Insulin-like growth factors I and II and their binding proteins in human milk: effect of heat treatment on IGF and IGF binding protein stability. J Pediatr Gastroenterol Nutr. 1991;13:242–253. - PubMed
    1. Beck F, Samani NJ, Penschow JD, Thorley B, Tregear GW, Coghlan JP. Histochemical localization of IGF-I and -II mRNA in the developing rat embryo. Development. 1987;101:175–184. - PubMed
    1. Dvorak B, Stephana AL, Holubec H, Williams CS, Philipps AF, Koldovsky O. Insulin-like growth factor-I (IGF-I) mRNA in the small intestine of suckling and adult rats. FEBS Lett. 1996;388:155–160. - PubMed

MeSH terms