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. 1991 Oct;10(10):2839-48.
doi: 10.1002/j.1460-2075.1991.tb07833.x.

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130

D P Gearing  1 , C J Thut, T VandeBos, S D Gimpel, P B Delaney, J King, V Price, D Cosman, M P Beckmann
Affiliations

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130

D P Gearing et al. EMBO J. 1991 Oct.

Abstract

Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence.

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