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Case Reports
. 2009 Mar;123(3):704-5.
doi: 10.1016/j.jaci.2008.11.035. Epub 2009 Jan 18.

Pathogenicity of IgE in autoimmunity: successful treatment of bullous pemphigoid with omalizumab

Janet A Fairley, Christian L Baum, Debra S Brandt, Kelly A N Messingham
Case Reports

Pathogenicity of IgE in autoimmunity: successful treatment of bullous pemphigoid with omalizumab

Janet A Fairley et al. J Allergy Clin Immunol. 2009 Mar.
No abstract available

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Figures

Figure 1
Figure 1. Bullous pemphigoid patient before and after omalizumab therapy
A, Abdominal involvement of steroid refractory BP patient prior to omalizumab therapy. B, Sixteen weeks after beginning omalizumab treatment the tense blisters and inflammatory plaques had resolved, leaving post-inflammatory hyperpigmentation and a small number of 4–6 mm erosions.
See this image and copyright information in PMC

References

    1. Dimson OG, Giudice GJ, Fu C-L, Warren SJ, Janson MM, Fairley JA. Identification of a Potential Effector Function for IgE Autoantibodies in the Organ-Specific Autoimmune Disease Bullous Pemphigoid. J Invest Dermatol. 2003;120:784–788. - PubMed
    1. Fairley JA, Fu CL, Giudice GJ. Mapping the binding sites of BP180 IgE autoantibodies in bullous pemphigoid. J Invest Dermatol. 2005;125:467–472. - PubMed
    1. Zone JJ, Taylor T, Hull C, Schmidt L, Meyer L. IgE basement membrane zone antibodies induce eosinophil infiltration and histological blisters in engrafted human skin on SCID mice. J Invest Dermatol. 2007;127:1167–1174. - PubMed
    1. Fairley JA, Burnett CT, Fu C-L, Larson DL, Fleming MG, Giudice GJ. A pathogenic role for IgE in autoimmunity: Bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice. J Invest Dermatol. 2007;127:2605–2611. - PubMed
    1. Holgate ST, Djukananovic R, Casale T, Bousquet J. Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin Exp Allergy. 2005;35:408–416. - PubMed

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