Comment
doi: 10.1016/j.devcel.2008.12.008.
Relaying the checkpoint signal from kinetochore to APC/C
Affiliations
- PMID: 19154713
- DOI: 10.1016/j.devcel.2008.12.008
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Comment
Relaying the checkpoint signal from kinetochore to APC/C
Dev Cell.
2009 Jan.
Free article
Abstract
The mitotic checkpoint delays chromosome segregation until the last chromosome has correctly attached to the spindle. Exactly how this unattached chromosome can generate a checkpoint signal and inhibit the anaphase promoting complex/cyclosome (APC/C) is unknown. Two Developmental Cell papers in this issue by Kulukian et al. and Malureanu et al. now provide insight into how checkpoint components Mad2 and BubR1 relay the checkpoint signal from kinetochores to APC/C.
Comment on
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Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.Dev Cell. 2009 Jan;16(1):105-17. doi: 10.1016/j.devcel.2008.11.005. Dev Cell. 2009. PMID: 19154722 Free PMC article.
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BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase.Dev Cell. 2009 Jan;16(1):118-31. doi: 10.1016/j.devcel.2008.11.004. Dev Cell. 2009. PMID: 19154723 Free PMC article.
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