The distinct roles of JAM-A in reovirus pathogenesis
- PMID: 19154981
- DOI: 10.1016/j.chom.2008.12.009
The distinct roles of JAM-A in reovirus pathogenesis
Abstract
Despite their fundamental role in host defense, many components of epithelial and endothelial tight junctions serve as viral receptors. In this issue of Cell Host & Microbe, Antar et al. (2009) provide striking in vivo evidence that the broadly expressed reovirus receptor JAM-A plays a specific role in reovirus dissemination.
Comment on
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Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus.Cell Host Microbe. 2009 Jan 22;5(1):59-71. doi: 10.1016/j.chom.2008.12.001. Cell Host Microbe. 2009. PMID: 19154988 Free PMC article.
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