Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009 Feb;113(2 Pt 2):480-483.
doi: 10.1097/AOG.0b013e31818fdf34.

Life-saving effects of fetal tracheal occlusion on pulmonary hypoplasia from preterm premature rupture of membranes

Thomas Kohl  1 , Annegret Geipel, Kristina Tchatcheva, Rüdiger Stressig, Winfried A Willinek, Ulrich Gembruch, Andreas Müller
Affiliations
Case Reports

Life-saving effects of fetal tracheal occlusion on pulmonary hypoplasia from preterm premature rupture of membranes

Thomas Kohl et al. Obstet Gynecol. 2009 Feb.

Abstract

Background: Preterm premature rupture of membranes before 22 weeks of gestation may result in severe fetal pulmonary hypoplasia. Fetoscopic tracheal balloon occlusion might result in catch-up pulmonary growth.

Case: After preterm premature rupture of membranes at 16 weeks of gestation, magnetic resonance imaging at 26 0/7 weeks showed a fetal lung volume of 13 mL and pulmonary blood flow hardly could be detected. Fetoscopic tracheal balloon occlusion was performed at 27 6/7 weeks; within 6 days, fetal lung volume increased to 70 mL and lung blood flow normalized. The fetus was delivered electively at 28 6/7 weeks. Six hours after delivery, the neonate required only 21% oxygen and was extubated after 55 hours.

Conclusion: Short-term fetoscopic tracheal balloon occlusion may result in rapid normalization of fetal lung volume and blood flow in fetuses with life-threatening pulmonary hypoplasia from preterm premature rupture of membranes before 22 weeks of gestation.

PubMed Disclaimer

References

    1. Kilbride HW, Yeast J, Thibeault DW. Defining limits of survival: lethal pulmonary hypoplasia after midtrimester premature rupture of membranes. Am J Obstet Gynecol 1996; 109 175–81.
    1. Laudy JA, Tibboel D, Robben SG, de Krijger RR, de Ridder MA, Wladimiroff JW. Prenatal prediction of pulmonary hypoplasia: Clinical, biometric and Doppler velocity correlates. Pediatrics 2002;109:250–8.
    1. Quintero RA, Romero R, Dzieczkowski J, Mammen E, Evans MI. Sealing of ruptured amniotic membranes with intra-amniotic platelet-cryoprecipitate plug. Lancet 1996;347:1117.
    1. De Carolis MP, Romagnoli C, De Santis M, Piersigilli F, Vento G, Caruso A. Is there significant improvement in neonatal outcome after treating pPROM mothers with amnio-infusion. Biol Neonate 2004;86:222–9.
    1. Tan LK, Kumar S, Jolly M, Gleeson C, Johnson P, Fisk NM. Test amnioinfusion to determine suitability for serial therapeutic amnioinfusion in midtrimester premature rupture of membranes. Fetal Diagn Ther 2003;18:183–9.

Publication types

LinkOut - more resources