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. 2009 Jun;17(6):844-7.
doi: 10.1038/ejhg.2008.259. Epub 2009 Jan 21.

IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients

Nicolas Couturier  1 , Pierre-Antoine Gourraud, Isabelle Cournu-Rebeix, Claire Gout, Florence Bucciarelli, Gilles Edan, Marie-Claude Babron, Françoise Clerget-Darpoux, Michel Clanet, Bertrand Fontaine, David Brassat
Affiliations

IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients

Nicolas Couturier et al. Eur J Hum Genet. 2009 Jun.

Abstract

A recent investigation reported, for the first time, an association between variants in the IFIH1-GCA-KCNH7 locus and multiple sclerosis (MS). We sought to replicate this genetic association in MS with a new independent MS cohort composed of French Caucasian MS trio families. The two most significant IFIH1 single nucleotide polymorphisms, rs1990760 and rs2068330, reported as involved in MS susceptibility, were genotyped in 591 French Caucasian MS trio families, and analyzed using the transmission/disequilibrium test. No association with MS was found (rs1990760, P=0.45 and rs2068330, P=0.27). Similarly, no significant association was detected after stratification for HLA-DRB1*1501 carriers. Reasons that may explain this discrepancy between the original report and our study are discussed.

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References

    1. Brassat D, Oksenberg J.Genetics of multiple sclerosisin Research signpost (eds):: Molecular Bases of Neurodegeneration 200543–49.
    1. Dyment DA, Ebers GC, Sadovnick AD. Genetics of multiple sclerosis. Lancet Neurol. 2004;3:104–110. - PubMed
    1. Hafler DA, Compston A, Sawcer S, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007;357:851–862. - PubMed
    1. Lundmark F, Duvefelt K, Iacobaeus E, et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet. 2007;39:1108–1113. - PubMed
    1. Gregory SG, Schmidt S, Seth P, et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet. 2007;39:1083–1091. - PubMed

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