Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jan;57(1):18-21.
doi: 10.2310/JIM.0b013e3181946fb2.

Designer natriuretic peptides

Candace Y W Lee  1 , Hsiao Lieu, John C Burnett Jr
Affiliations
Review

Designer natriuretic peptides

Candace Y W Lee et al. J Investig Med. 2009 Jan.

Abstract

Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Amino acid structures for atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), C-type natriuretic peptide (CNP), Dendroaspis natriuretic peptide (DNP), and urodilatin (URO).
FIGURE 2
FIGURE 2
Amino acid structures for vasonatrin (VNP).
FIGURE 3
FIGURE 3
Fusion peptide of C-type natriuretic peptide and C-terminus of Dendroapsis natriuretic peptide (CD-NP).
See this image and copyright information in PMC

References

    1. Wei CM, Kim CH, Miller VM, et al. Vasonatrin peptide: a unique synthetic natriuretic and vasorelaxing peptide. J Clin Invest. 1993;92:2048–2052. - PMC - PubMed
    1. de Bold AJ, Borenstein HB, Veress AT, et al. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981;28:89–94. - PubMed
    1. Sudoh T, Kangawa K, Minamino N, et al. A new natriuretic peptide in porcine brain. Nature. 1988;332:78–81. - PubMed
    1. Sudoh T, Minamino N, Kangawa K, et al. C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun. 1990;168:863–870. - PubMed
    1. Schulz-Knappe P, Forssmann K, Herbst F, et al. Isolation and structural analysis of “urodilatin,” a new peptide of the cardiodilatin-(ANP)-family, extracted from human urine. Klin Wochenschr. 1988;66:752–759. - PubMed

Publication types

Substances