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Review
. 2009 Jan;57(1):18-21.
doi: 10.2310/JIM.0b013e3181946fb2.

Designer natriuretic peptides

Affiliations
Review

Designer natriuretic peptides

Candace Y W Lee et al. J Investig Med. 2009 Jan.

Abstract

Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed.

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Figures

FIGURE 1
FIGURE 1
Amino acid structures for atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), C-type natriuretic peptide (CNP), Dendroaspis natriuretic peptide (DNP), and urodilatin (URO).
FIGURE 2
FIGURE 2
Amino acid structures for vasonatrin (VNP).
FIGURE 3
FIGURE 3
Fusion peptide of C-type natriuretic peptide and C-terminus of Dendroapsis natriuretic peptide (CD-NP).

References

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