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. 2009 Feb 19;11(4):999-1002.
doi: 10.1021/ol8029593.

A versatile approach to beta-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis

Tri H V Huynh  1 , Mette Louise H Mantel, Katrine Mikkelsen, Anders T Lindhardt, Niels Chr Nielsen, Daniel Otzen, Troels Skrydstrup
Affiliations

A versatile approach to beta-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis

Tri H V Huynh et al. Org Lett. .

Abstract

Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of beta-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and (19)F-BAY94-9172.

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