Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jan;72(1):14-7.
doi: 10.1021/np8003529.

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A

Roger G Linington  1 , Benjamin R Clark, Erin E Trimble, Alejandro Almanza, Luis-David Ureña, Dennis E Kyle, William H Gerwick
Affiliations

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A

Roger G Linington et al. J Nat Prod. 2009 Jan.

Abstract

As part of a continuing program to identify novel treatments for neglected parasitic diseases, the Panama International Cooperative Biodiversity Group (ICBG) program has been investigating the antimalarial potential of secondary metabolites from Panamanian marine cyanobacteria. From over 60 strains of cyanobacteria evaluated in our biological screens, the organic extract of a Schizothrix species from a tropical reef near Piedras Gallinas (Caribbean coast of Panama) showed potent initial antimalarial activity against the W2 chloroquine-resistant strain of Plasmodium falciparum. Bioassay-guided fractionation followed by 2D NMR analysis afforded the planar structure of a new and highly functionalized linear peptide, gallinamide A. Subsequent degradation and derivatization methods were used to determine the absolute configuration at most stereogenic centers in this unusual new metabolite.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Subunits a – e and selected ROESY correlations for 1.
Figure 1
Figure 1
Subunits a – e and selected ROESY correlations for 1.
See this image and copyright information in PMC

References

    1. Nwaka S, Ridley RG. Nat. Rev. Drug Discovery. 2003;2:919–928. - PubMed
    1. Gelb MH. Curr. Opin. Chem. Biol. 2007;11:440–445. - PMC - PubMed
    1. McPhail KL, Correa J, Linington RG, González J, Ortega-Barría E, Capson TL, Gerwick WH. J. Nat. Prod. 2007;70:984–988. - PMC - PubMed
    1. Linington RG, González J, Ureña L-D, Romero LI, Ortega-Barría E, Gerwick WH. J. Nat. Prod. 2007;70:397–401. - PubMed
    1. Giddens AC, Nielsen L, Boshoff HI, Tasdemir D, Perozzo R, Kaiser M, Wang F, Sacchettini JC, Copp BR. Tetrahedron. 2008;64:1242–1249.

Publication types

MeSH terms