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. 2009 Jun 15;89(1):2-3.
doi: 10.1016/j.exer.2008.12.016. Epub 2009 Jan 8.

Focus on molecules: guanylate cyclase-activating proteins (GCAPs)

Wolfgang Baehr  1 , Krzysztof Palczewski
Affiliations

Focus on molecules: guanylate cyclase-activating proteins (GCAPs)

Wolfgang Baehr et al. Exp Eye Res. .
No abstract available

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Figures

Figure 1
Figure 1
Structure of Ca2+-bound, myristoylated GCAP1 (pdb 2R2I, generated in pymol). Helices are coded in rainbow colors; Ca2+ is represented by red balls. The EF-hand loops are identified by EF1–4. ‘myr’ denotes the N-terminal myristoyl group buried between the C-terminal (green) and the N-terminal helix (blue). The N- and C-terminal ends are indicated with colored boxes.
See this image and copyright information in PMC

References

    1. Baehr W, Karan S, Maeda T, Luo DG, Li S, Bronson JD, Watt CB, Yau KW, Frederick JM, Palczewski K. The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem. 2007;282:8837–8847. - PMC - PubMed
    1. Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W. A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res. 2008;48:2425–2432. - PMC - PubMed
    1. Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS, Walsh KA, Gray-Keller MP, Detwiler PB, Baehr W. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase activating protein (GCAP) Neuron. 1994;13:395–404. - PubMed
    1. Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC. Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure. 2007;15:1392–1402. - PMC - PubMed

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