Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Feb 15;207(1-2):107-10.
doi: 10.1016/j.jneuroim.2008.11.010. Epub 2009 Jan 21.

Changes in circulating dendritic cells and B-cells in patients with multiple sclerosis relapse during corticosteroid therapy

Mitosek-Szewczyk Krystyna  1 , Tabarkiewicz Jacek, Radej Sebastian, Belniak Ewa, Bartosik-Psujek Halina, Stelmasiak Zbigniew, Rolinski Jacek
Affiliations

Changes in circulating dendritic cells and B-cells in patients with multiple sclerosis relapse during corticosteroid therapy

Mitosek-Szewczyk Krystyna et al. J Neuroimmunol. .

Abstract

We studied dendritic, myeloid (mDCs) (BDCA1+/CD19-) and plasmacytoid cells (pDCs) (BDCA2+/CD123+) and B-cells (CD19+) at relapse, after short intravenous methyloprednisolone therapy and 30 days after treatment completion (remission period) and results were compared with a control group of healthy volunteers. We confirmed the decrease in BDCA2+/CD123+ after therapy (p=0.00006) and then an increase (p=0.0032) in comparison to the control group. The level of B CD19+ cells after GC therapy increased compared to the control group (p=0.00809) and had stabilised 30 days after therapy. The effect of methyloprednisolone on DC function and B-cell levels thus changes.

PubMed Disclaimer

MeSH terms

LinkOut - more resources