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. 2009 Apr;23(3):369-73.
doi: 10.1016/j.janxdis.2008.12.005. Epub 2008 Dec 25.

Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure

Ananda B Amstadter  1 , Karestan C Koenen, Kenneth J Ruggiero, Ron Acierno, Sandro Galea, Dean G Kilpatrick, Joel Gelernter
Affiliations

Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure

Ananda B Amstadter et al. J Anxiety Disord. 2009 Apr.

Abstract

Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were found to be associated with anxious behavior in mice and anxiety in humans. We examined whether rs4606, a single nucleotide polymorphism (SNP) of RGS2, and social support moderated risk for PTSD in an epidemiologic sample. The study examines 607 adults from the 2004 Florida Hurricanes study who returned buccal DNA samples via mail. rs4606 was associated with increased symptoms of posthurricane PTSD symptoms under conditions of high hurricane exposure and low social support (P<.05). Further, this polymorphism was associated with lifetime PTSD symptoms under conditions of lifetime exposure to a potentially traumatic event, and low social support (P<.001). These gene by environment interactions remained significant after adjustment for sex, ancestry, and age. RGS2 rs4606 modifies risk of postdisaster and lifetime PTSD symptoms under conditions of high stressor exposure. This is the first demonstration of gene-environment interaction for this locus.

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Conflict of interest statement

The authors declare no conflicting financial or other competing interests.

Figures

Figure 1
Figure 1. Lifetime PTSD Symptoms by Risk Group
Note: Low risk group is those with ‘G/G’ genotype, high social support, and low PTE. Medium risk group is those with ‘C/G’ genotype, low social support, and high PTE. High risk group is those with ‘C/C’ genotype, low social support, high PTE. This is the same pattern found for post-hurricane symptoms.
See this image and copyright information in PMC

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