Proteins of bovine leukemia virus. I. Characterization and reactions with natural antibodies
- PMID: 191635
- PMCID: PMC515645
- DOI: 10.1128/JVI.21.3.1056-1060.1977
Proteins of bovine leukemia virus. I. Characterization and reactions with natural antibodies
Abstract
The bovine leukemia virus (BLV) was purified from a chronically infected fetal lamb kidney cell line. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of this virus revealed the presence of eight distinguishable viral components with molecular weights ranging from 80,000 to 11,000. The major component is a non-glycosylated protein having a molecular weight of 24,000 (p24). At least three heavier polypeptides were found, one of them representing a glycoprotein (gp 60). In addition, four minor polypeptides with respective molecular weights of 19,000, 16,000, 13,000, and 11,000 were identified. In a complement fixation assay using naturally occurring antibodies of a leukemic cow, four polypeptides, which included gp 60, p35, p24, and p16, were found to be reactive.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials