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. 1977 Mar;21(3):1205-9.
doi: 10.1128/JVI.21.3.1205-1209.1977.

Chromatin-like structures obtained after alkaline disruption of bovine and human papillomaviruses

M Favre, F Breitburd, O Croissant, G Orth

Chromatin-like structures obtained after alkaline disruption of bovine and human papillomaviruses

M Favre et al. J Virol. 1977 Mar.

Abstract

Four low-molecular-weight polypeptides migrating like H2a, H2b, H3, and H4 calf liver histones were detected by sodium dodecyl sulfate-acrylamide gel electrophoresis of highly purified preparations of bovine papillomavirus (BPV) and human papillomavirus (HPV). Complexes of these polypeptides and viral DNA were isolated by agarose-gel filtration of the alkaline disruption products of both viruses. When observed under the electron microscope, these complexes appeared as circular structures composed of nucleosomes with a diameter of about 8.0 nm interconnected by a naked DNA filament. The maximal frequency of nucleosomes per molecule was 30 for both viruses, corresponding to a condensation ratio of the viral DNA of 2.5.

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References

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