Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2009 Mar;40(3):672-3.
doi: 10.1161/STROKEAHA.108.532051. Epub 2009 Jan 22.

Are unadjusted analyses of clinical trials inappropriately biased toward the null?

David M Kent, Thomas A Trikalinos, Michael D Hill
Editorial

Are unadjusted analyses of clinical trials inappropriately biased toward the null?

David M Kent et al. Stroke. 2009 Mar.
No abstract available

PubMed Disclaimer

Comment on

References

    1. Kent DM, Hayward RA. Limitations of applying summary results of clinical trials to individual patients: the need for risk stratification. JAMA. 2007 Sep 12;298(10):1209–12. - PubMed
    1. Kent DM, Hayward RA. When averages hide individual differences in clinical trials. American Scientist. 2007;95:60–8.
    1. Gray LJ, Bath P, Collier T. Should stroke trials adjust for functional outcome for baseline prognostic factors? Stroke - PubMed
    1. Choi SC. Sample size in clinical trials with dichotomous endpoints: use of covariables. Journal of Biopharmaceutical Statistics. 1998 Jul.8(3):367–75. - PubMed
    1. Johnston KC, Connors AF, Wagner DP, Haley EC. Risk adjustment effect on stroke clinical trials. Stroke. 2004;35:e43–e45. - PMC - PubMed