Review
doi: 10.1161/ATVBAHA.108.179663.
Epub 2009 Jan 22.
Vascular endothelial growth factor
Affiliations
- PMID: 19164810
- DOI: 10.1161/ATVBAHA.108.179663
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Review
Vascular endothelial growth factor
Arterioscler Thromb Vasc Biol.
2009 Jun.
Abstract
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
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