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Review
. 2009 Jun;29(6):789-91.
doi: 10.1161/ATVBAHA.108.179663. Epub 2009 Jan 22.

Vascular endothelial growth factor

Napoleone Ferrara  1
Affiliations
Review

Vascular endothelial growth factor

Napoleone Ferrara. Arterioscler Thromb Vasc Biol. 2009 Jun.

Abstract

Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.

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