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Comment
. 2008 Sep;40(9):1032-4; author reply 1035-6.
doi: 10.1038/ng0908-1032.

Variation in KLK genes, prostate-specific antigen and risk of prostate cancer

Jiyoung Ahn, Sonja I Berndt, Sholom Wacholder, Peter Kraft, Adam S Kibel, Meredith Yeager, Demetrius Albanes, Edward Giovannucci, Meir J Stampfer, Jarmo Virtamo, Michael J Thun, Heather Spencer Feigelson, Geraldine Cancel-Tassin, Olivier Cussenot, Gilles Thomas, David J Hunter, Joseph F Fraumeni Jr, Robert N Hoover, Stephen J Chanock, Richard B Hayes
Comment

Variation in KLK genes, prostate-specific antigen and risk of prostate cancer

Jiyoung Ahn et al. Nat Genet. 2008 Sep.
No abstract available

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Figures

Figure 1
Figure 1. Associations of tagSNPs in the KLK region with PSA concentrations and prostate cancer risk in the PLCO Trial
A) P values for association of KLK3 with serum PSA concentrations in the control group (2df test). B) P values for association of KLK3 with prostate cancer risk (2df test); the blue triangles represent p values for the association when we restricted the control group to men with low PSA (<0.5 ng/ml). The red circles represent p values for the association when we did not restrict the control group to men with low PSA.
See this image and copyright information in PMC

Comment on

  • Multiple newly identified loci associated with prostate cancer susceptibility.
    Eeles RA, Kote-Jarai Z, Giles GG, Olama AA, Guy M, Jugurnauth SK, Mulholland S, Leongamornlert DA, Edwards SM, Morrison J, Field HI, Southey MC, Severi G, Donovan JL, Hamdy FC, Dearnaley DP, Muir KR, Smith C, Bagnato M, Ardern-Jones AT, Hall AL, O'Brien LT, Gehr-Swain BN, Wilkinson RA, Cox A, Lewis S, Brown PM, Jhavar SG, Tymrakiewicz M, Lophatananon A, Bryant SL; UK Genetic Prostate Cancer Study Collaborators; British Association of Urological Surgeons' Section of Oncology; UK ProtecT Study Collaborators; Horwich A, Huddart RA, Khoo VS, Parker CC, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Fisher C, Jamieson C, Cooper CS, English DR, Hopper JL, Neal DE, Easton DF. Eeles RA, et al. Nat Genet. 2008 Mar;40(3):316-21. doi: 10.1038/ng.90. Epub 2008 Feb 10. Nat Genet. 2008. PMID: 18264097

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