Old nuclei spring new leaks
- PMID: 19167324
- DOI: 10.1016/j.cell.2009.01.004
Old nuclei spring new leaks
Abstract
The nuclear pore complex (NPC) regulates the bidirectional movement of cell components across the nuclear envelope. In this issue, D'Angelo et al. (2009) demonstrate that the NPC loses essential protein subunits as cells age, resulting in increased nuclear permeability and potentially contributing to organismal aging.
Comment on
-
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.Cell. 2009 Jan 23;136(2):284-95. doi: 10.1016/j.cell.2008.11.037. Cell. 2009. PMID: 19167330 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
