Acute tolerance to opioids: methodological, theoretical and clinical implications
- PMID: 19167820
- DOI: 10.1016/j.pain.2009.01.004
Acute tolerance to opioids: methodological, theoretical and clinical implications
Comment on
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No evidence for the development of acute tolerance to analgesic, respiratory depressant and sedative opioid effects in humans.Pain. 2009 Mar;142(1-2):17-26. doi: 10.1016/j.pain.2008.11.001. Epub 2009 Jan 9. Pain. 2009. PMID: 19135798 Clinical Trial.