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. 2009 Jan;62(1):51-3.

Diarrhea as a minor adverse effect due to oral polio vaccine

Tamie Sugawara  1 , Yasushi Ohsuka, Keiko Taya, Yoshinori Yasui, Noriyuki Wada, Masasi Sakano, Rie Koshida, Fumitoshi Fujii, Senko Shibata, Goutaro Hashimoto, Hiromi Utsumi, Masami Sumitomo, Michiyo Ishihara, Hirokazu Kondo, Hiroshi Sato, Kumi Ueno, Kazuko Araki, Nobuhiko Okabe
Affiliations
  • PMID: 19168959

Diarrhea as a minor adverse effect due to oral polio vaccine

Tamie Sugawara et al. Jpn J Infect Dis. 2009 Jan.

Abstract

Using the adverse events monitoring system of Japan, we observed diarrhea cases in approximately 10% of patients who received oral poliovirus vaccine (OPV). This study was conducted to investigate whether diarrhea among children aged 0 to 1 is caused by OPV or by other factors such contact at the doctor's office and/or with others outside the home. We conducted a survey of the health of children after regular health check-ups and after the administration of the OPV. The data from the health check-ups were used as a control for the OPV case group. We compared the first-OPV dose vaccination group as well as the second-OPV dose vaccination group to the health check-up group. For cases of diarrhea, the odds ratio of the OPV group to the health check-up group was 1.776. Our findings strongly suggest that post-OPV cases of mild diarrhea are closely related to the administration of the OPV.

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