Regulation of MHC expression

Abstract

The level of expression of class I and class II MHC antigens in any particular cell is not a fixed characteristic, but is subject to wide fluctuation. The "resting" level of expression varies widely in different cell types, e.g., the cells of the exocrine pancreas and the myocardial cell express neither class I nor class II MHC antigens, whereas B lymphocytes express high levels of both class I and class II. The factors regulating these resting levels are beginning to be elucidated at the DNA level. The resting levels of class I and class II MHC antigen expression can be very greatly increased, primarily as a consequence of exposure to various cytokines released during inflammatory responses, but also in response to other non-specific stimuli. This probably represents an evolutionary adaptation to increase the capacity of infected tissues to present foreign peptides to the immune system, and thereby favour the survival of the host. However, when this phenomenon occurs in a transplanted organ, the increased expression of the now foreign MHC antigens in the context of the new host very likely plays a role in the graft's own destruction. The increased expression of class I MHC antigens, especially if the cell does not express these antigens at all at the time of grafting, will very likely render the cell susceptible to CD8+ cytotoxic T lymphocytes.(ABSTRACT TRUNCATED AT 250 WORDS)