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. 2009 Feb;41(2):205-10.
doi: 10.1038/ng.310. Epub 2009 Jan 25.

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

Xue-Jun Zhang  1 , Wei Huang, Sen Yang, Liang-Dan Sun, Feng-Yu Zhang, Qi-Xing Zhu, Fu-Ren Zhang, Chi Zhang, Wen-Hui Du, Xiong-Ming Pu, Hui Li, Feng-Li Xiao, Zai-Xing Wang, Yong Cui, Fei Hao, Jie Zheng, Xue-Qin Yang, Hui Cheng, Chun-Di He, Xiao-Ming Liu, Li-Min Xu, Hou-Feng Zheng, Shu-Mei Zhang, Jian-Zhong Zhang, Hong-Yan Wang, Yi-Lin Cheng, Bi-Hua Ji, Qiao-Yun Fang, Yu-Zhen Li, Fu-Sheng Zhou, Jian-Wen Han, Cheng Quan, Bin Chen, Jun-Lin Liu, Da Lin, Li Fan, An-Ping Zhang, Sheng-Xiu Liu, Chun-Jun Yang, Pei-Guang Wang, Wen-Ming Zhou, Guo-Shu Lin, Wei-Dong Wu, Xing Fan, Min Gao, Bao-Qi Yang, Wen-Sheng Lu, Zheng Zhang, Kun-Ju Zhu, Song-Ke Shen, Min Li, Xiao-Yan Zhang, Ting-Ting Cao, Wei Ren, Xin Zhang, Jun He, Xian-Fa Tang, Shun Lu, Jian-Qiang Yang, Lin Zhang, Dan-Ni Wang, Feng Yuan, Xian-Yong Yin, Hong-Jie Huang, Hai-Feng Wang, Xin-Yi Lin, Jian-Jun Liu
Affiliations

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

Xue-Jun Zhang et al. Nat Genet. 2009 Feb.

Abstract

We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ancestry using Illumina Human 610-Quad BeadChips. In the second stage, we took top SNPs forward for replication in two independent samples of 5,182 cases and 6,516 controls of Chinese Han ancestry, and 539 cases and 824 controls of Chinese Uygur ancestry. In addition to the strong replication for two known susceptibility loci MHC (rs1265181, P = 1.93 x 10(-208), OR = 22.62) and IL12B (rs3213094, P(combined) = 2.58 x 10(-26), OR = 0.78), we identified a new susceptibility locus within the LCE gene cluster on 1q21 (rs4085613, P(combined) = 6.69 x 10(-30), OR = 0.76).

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