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. 2009;48(9):1636-9.
doi: 10.1002/anie.200805652.

Oxindole synthesis by direct coupling of C(sp2)-H and C(sp3)-H centers

Yi-Xia Jia  1 , E Peter Kündig
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Oxindole synthesis by direct coupling of C(sp2)-H and C(sp3)-H centers

Yi-Xia Jia et al. Angew Chem Int Ed Engl. 2009.

Abstract

An sp(2)/sp(3) get-together: A novel and efficient method can be used to synthesize 3,3-disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl C(sp(2))-H and a C(sp(3))-H center (see scheme; DMF = N,N-dimethylformamide).

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