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. 2009 Feb 20;74(4):1759-62.
doi: 10.1021/jo802285r.

An efficient carbene-catalyzed access to 3,4-dihydrocoumarins

Kirsten Zeitler  1 , Christopher A Rose
Affiliations

An efficient carbene-catalyzed access to 3,4-dihydrocoumarins

Kirsten Zeitler et al. J Org Chem. .

Abstract

Dihydrocoumarins play an important role as flavor and fragrance compounds and can be prepared efficiently from o-hydroxycinnamaldehydes in a mild, atom-economic N-heterocyclic carbene-catalyzed redox lactonization. Corresponding coumarins are accessible via a one-pot domino oxidation lactonization procedure in the presence of oxidants.

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