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. 2009 Jan;57(1):55-61.
doi: 10.1111/j.1532-5415.2008.02092.x.

Persistent delirium predicts greater mortality

Dan K Kiely  1 , Edward R Marcantonio, Sharon K Inouye, Michele L Shaffer, Margaret A Bergmann, Frances M Yang, Michael A Fearing, Richard N Jones
Affiliations

Persistent delirium predicts greater mortality

Dan K Kiely et al. J Am Geriatr Soc. 2009 Jan.

Abstract

Objectives: To examine the association between persistent delirium and 1-year mortality in newly admitted postacute care (PAC) facility patients with delirium who were followed regardless of residence.

Design: Observational cohort study.

Setting: Eight greater-Boston skilled nursing facilities specializing in PAC.

Participants: Four hundred twelve PAC patients with delirium at admission after an acute hospitalization.

Measurements: Assessments were done at baseline and four follow-up times: 2, 4, 12, and 26 weeks. Delirium, defined using the Confusion Assessment Method, was assessed, as were factors used as covariates in analyses: age, sex, comorbidity, functional status, and dementia. The outcome was 1-year mortality determined according to the National Death Index and corroborated using medical record and proxy telephone interview.

Results: Nearly one-third of subjects remained delirious at 6 months. Cumulative 1-year mortality was 39%. Independent of age, sex, comorbidity, functional status, and dementia, subjects with persistent delirium were 2.9 (95% confidence interval 51.9-4.4) times as likely to die during the 1-year follow-up as subjects whose delirium resolved. This association remained strong and significant in groups with and without dementia. Additionally, when delirium resolved, the risk of death diminished thereafter.

Conclusion: In patients who were delirious at the time of PAC admission, persistent delirium was a significant independent predictor of 1-year mortality.

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Conflict of interest statement

Conflict of Interest: The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any other kind of personal conflicts with this paper.

Figures

Figure 1
Figure 1
Estimated survival curves of the time to death for five delirium resolution patterns. Estimated survival obtained from discrete time survival models fitted with general baseline hazard and a constant risk of death due to delirium. Parameters were estimated with logistic regression. Y = Delirium Present; N = Delirium Not Present. PAC = post-acute care.
See this image and copyright information in PMC

References

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