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Case Reports
. 2009 Apr;47(4):1244-8.
doi: 10.1128/JCM.02030-08. Epub 2009 Jan 26.

Mucor circinelloides as a cause of invasive maxillofacial zygomycosis: an emerging dimorphic pathogen with reduced susceptibility to posaconazole

Zia U Khan  1 , Suhail Ahmad, Arnost Brazda, Rachel Chandy
Affiliations
Case Reports

Mucor circinelloides as a cause of invasive maxillofacial zygomycosis: an emerging dimorphic pathogen with reduced susceptibility to posaconazole

Zia U Khan et al. J Clin Microbiol. 2009 Apr.

Abstract

A case of maxillofacial zygomycosis caused by Mucor circinelloides, identified by phenotypic and molecular methods and treated successfully with liposomal amphotericin B (AmBisome) and surgical debridement, is described. The isolate was resistant to posaconazole. This report underscores the importance of prior susceptibility testing of zygomycetes to guide therapy with the most effective antifungal agent for an improved prognosis.

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Figures

FIG. 1.
FIG. 1.
(A) Branched circinate sporangiophores, sporangia, and collumellae; (B) chlamydospores of M. circinelloides formed successively in chains. Magnification, ×400.
FIG. 2.
FIG. 2.
(A and B) Growth of M. circinelloides in BHI agar at 37°C, showing hyphae with arthroconidium formation and yeast forms with single, bipolar, and multipolar buds. Magnification, ×600.
See this image and copyright information in PMC

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