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Comment
. 2009 Feb;9(2):81-2.
doi: 10.1038/nri2490.

Decision making during the conception and career of CD4+ T cells

Comment

Decision making during the conception and career of CD4+ T cells

Steven L Reiner. Nat Rev Immunol. 2009 Feb.

Abstract

The mechanisms by which thymocytes commit to becoming CD4+ T cells and how these cells subsequently can adopt various cell fates are becoming important paradigms of developmental programming. Understanding how such CD4+ T-cell diversity accommodates both immune reaction against various challenges and the suppression of undesirable responses is also revealing new therapeutic options.

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