Decision making during the conception and career of CD4+ T cells
- PMID: 19172726
- DOI: 10.1038/nri2490
Decision making during the conception and career of CD4+ T cells
Abstract
The mechanisms by which thymocytes commit to becoming CD4+ T cells and how these cells subsequently can adopt various cell fates are becoming important paradigms of developmental programming. Understanding how such CD4+ T-cell diversity accommodates both immune reaction against various challenges and the suppression of undesirable responses is also revealing new therapeutic options.
Comment on
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Epigenetic control of T-helper-cell differentiation.Nat Rev Immunol. 2009 Feb;9(2):91-105. doi: 10.1038/nri2487. Nat Rev Immunol. 2009. PMID: 19151746 Review.
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RUNX proteins in transcription factor networks that regulate T-cell lineage choice.Nat Rev Immunol. 2009 Feb;9(2):106-15. doi: 10.1038/nri2489. Nat Rev Immunol. 2009. PMID: 19165227 Free PMC article. Review.
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