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. 1991;18(5):563-4.
doi: 10.1016/0883-2897(91)90119-6.

Synthesis and biodistribution of 123I N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide (Ro 43-0463), a monoamine oxidase B inhibitor

S E Macwhorter  1 , R M Baldwin
Affiliations

Synthesis and biodistribution of 123I N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide (Ro 43-0463), a monoamine oxidase B inhibitor

S E Macwhorter et al. Int J Rad Appl Instrum B. 1991.

Abstract

N-(2-Aminoethyl)-5-iodo-2-pyridinecarboxamide (Ro 43-0463) was radiolabeled with 123I in 22% radiochemical yield by anionic isotopic exchange in acidic medium. Biodistribution studies of this radioligand in rats showed peak brain uptake of 0.50% of the injected dose at 30 min and slow washout over 60 min.

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