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Review
. 2009 May;82(2):A110-22.
doi: 10.1016/j.antiviral.2008.12.014. Epub 2009 Jan 25.

Animal models for the study of influenza pathogenesis and therapy

Dale L Barnard  1
Affiliations
Review

Animal models for the study of influenza pathogenesis and therapy

Dale L Barnard. Antiviral Res. 2009 May.

Abstract

Influenza A viruses causes a variety of illnesses in humans. The most common infection, seasonal influenza, is usually a mild, self-limited febrile syndrome, but it can be more severe in infants, the elderly, and immunodeficient persons, in whom it can progress to severe viral pneumonitis or be complicated by bacterial superinfection, leading to pneumonia and sepsis. Seasonal influenza also occasionally results in neurologic complications. Rarely, viruses that have spread from wild birds to domestic poultry can infect humans; such "avian influenza" can range in severity from mild conjunctivitis through the rapidly lethal disease seen in persons infected with the H5N1 virus that first emerged in Hong Kong in 1997. To develop effective therapies for this wide range of diseases, it is essential to have laboratory animal models that replicate the major features of illness in humans. This review describes models currently in use for elucidating influenza pathogenesis and evaluating new therapeutic agents.

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References

    1. Alarcon J.B., Hartley A.W., Harvey N.G., Mikszta J.A. Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines. Clin. Vaccine Immunol. 2007;14:375–381. - PMC - PubMed
    1. Alonso J.-M., Guiyoule A., Zarantonelli M.L., Ramisse F., Pires R., Antignac A., Deghmane A.E., Huerre M., van der Werf S., Taha M.-K. A model of meningococcal bacteremia after respiratory superinfection in influenza A virus-infected mice. FEMS Microbiol. Lett. 2003;222:99–106. - PubMed
    1. Aronsson F., Robertson B., Ljunggren H.G., Kristensson K. Invasion and persistence of the neuroadapted influenza virus A/WSN/33 in the mouse olfactory system. Viral Immunol. 2003;16:415–513. - PubMed
    1. Baas T., Baskin C.R., Diamond D.L., Garcia-Sastre A., Bielefeldt-Ohmann H., Tumpey T.M., Thomas M.J., Carter V.S., Teal T.H., Van Hoeven N., Proll S., Jacobs J.M., Caldwell Z.R., Gritsenko M.A., Hukkanen R.R., Camp D.G., II, Smith R.D., Katze M.G. Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics. J. Virol. 2006;80:10813–10828. - PMC - PubMed
    1. Barnard D.L., Wong M.-H., Bailey K., Day C.W., Sidwell R.W., Hickok S.S., Hall T.J. Effect of oral gavage treatment with ZnAL42 and other metallo-ion formulations on influenza A H5N1 and H1N1 virus infections in mice. Antivir. Chem. Chemother. 2007;18:125–132. - PubMed

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