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. 2009 Jan 29:4:6.
doi: 10.1186/1750-1326-4-6.

Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database

Kambiz N Alavian  1 , Horst H Simon
Affiliations

Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database

Kambiz N Alavian et al. Mol Neurodegener. .

Abstract

Midbrain dopaminergic neurons are involved in control of emotion, motivation and motor behavior. The loss of one of the subpopulations, substantia nigra pars compacta, is the pathological hallmark of one of the most prominent neurological disorders, Parkinson's disease. Several groups have looked at the molecular identity of midbrain dopaminergic neurons and have suggested the gene expression profile of these neurons. Here, after determining the efficiency of each screen, we provide a linked database of the genes, expressed in this neuronal population, by combining and comparing the results of six previous studies and verification of expression of each gene in dopaminergic neurons, using the collection of in situ hybridization in the Allen Brain Atlas.

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Figures

Figure 1
Figure 1
Expression pattern of known mesDA neuron-specific transcription factors and genes involved in dopamine neurotransmission in mouse brain. Three-dimensional view of Foxa2, En1, Th, Vmat2 (Slc18a2) and Dat (Slc6a3) expressions in the brain, superimposed on a sagittal nissl image from Allen Brain Atlas (ABA) are shown. The genes chosen for Neuroblast search have known functions in the adult mesDA neurons and are detected by ABA in ventral midbrain (arrow).
See this image and copyright information in PMC

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