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Comment
. 2009 Feb;75(4):353-5.
doi: 10.1038/ki.2008.554.

Collapsing glomerulopathy: beyond serendipity in mouse genetics

Peter J Nelson  1 , Leslie A Bruggeman
Affiliations
Comment

Collapsing glomerulopathy: beyond serendipity in mouse genetics

Peter J Nelson et al. Kidney Int. 2009 Feb.

Abstract

Clinical correlates suggest that collapsing glomerulopathy results from the pathogenic interaction between patients' intractable genetic susceptibilities and environmental insults. When the environmental insults include a virus that introduces its own pathogenic genes, the interactions become more complex. Chan et al. combine reverse and forward genetic techniques in mice toward understanding this complexity with HIV and identify candidate genetic modifiers of collapsing glomerulopathy.

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Conflict of interest statement

DISCLOSURE

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The interplay of forward and reverse genetics in identifying genetic disease components. Environmental factors may influence overall disease severity or progression, which may uncover additional secondary genetic factors that predispose to disease. Histopathology images adapted from Hallman et al. (used with permission).
See this image and copyright information in PMC

Comment on

References

    1. Wiggins RC. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int. 2007;71:1205–1214. - PubMed
    1. Albaqumi M, Soos TJ, Barisoni L, Nelson PJ. Collapsing glomerulopathy. J Am Soc Nephrol. 2006;17:2854–2863. - PubMed
    1. Chan KT, Martino J, Papeta N, Zheng Z, Frankel R, Klotman PE, D’Agati V, Lifton RP, Gharavi AG. Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus on chr 3A1-A3. Kidney Int. 2008 - PMC - PubMed
    1. Dickie P, Felser J, Eckhaus M, Bryant J, Silver J, Marinos N, Notkins AL. HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology. 1991;185:109–119. - PubMed
    1. Gharavi AG, Ahmad T, Wong RD, Hooshyar R, Vaughn J, Oller S, Frankel RZ, Bruggeman LA, D’Agati VD, Klotman PE, Lifton RP. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci U S A. 2004;101:2488–2493. - PMC - PubMed

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