doi: 10.1002/anie.200805427.
Evidence for a stereoelectronic effect in human oxygen sensing
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- PMID: 19180614
- DOI: 10.1002/anie.200805427
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Evidence for a stereoelectronic effect in human oxygen sensing
Angew Chem Int Ed Engl.
2009.
Abstract
How PHDs achieve specificity: trans-4-prolyl hydroxylation of the transcription factor HIF occurs with stereochemical retention. Substrate-analogue studies show how the von Hippel Lindau tumor suppressor protein (pVHL) and the oxygen-sensing hydroxylases (PHDs) achieve specificity for hydroxyprolyl/prolyl residues for the C(4)-exo/endo prolyl conformations, respectively.
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