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. 2008 Sep;31(9):1360-4.

[Effects of Xiaoyao Wan on the behavioral despair and stress depression mice]

[Article in Chinese]
Li Bao  1 , Jing Chen, Lin Huang, Wei Chen, Qing Lin, Xin-Sheng Yao, Kurihara Hiroshi
Affiliations
  • PMID: 19180959

[Effects of Xiaoyao Wan on the behavioral despair and stress depression mice]

[Article in Chinese]
Li Bao et al. Zhong Yao Cai. 2008 Sep.

Abstract

Objective: To investigate the anti-depressant effect and the possible mechanism of Xiaoyao Wan in animal models.

Methods: The open-field test and the forced swimming test were applied to study the anti-depressant effect of Xiaoyao Wan in mice, and HPLC-ECD was carried out to assay the contents of 5-HT and 5-HIAA, and the mechanism of Xiaoyao Wan on anti-depressant effect was discussed.

Results: Xiaoyao Wan at the dose of 200, 400 and 600 mg/kg significantly increased the revolutions in force swimming test, and ameliorated brain cortex 5-HT and 5-HIAA content of restraint mice. But there was no effect on brain cortex 5-HT and 5-HIAA content of non-restraint mice.

Conclusion: Xiaoyao Wan has significant anti-depressant effect which may be related to the potentiation of brain serotonergic function.

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