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Review
. 2009 Feb;64(2):171-4.
doi: 10.1093/gerona/gln058. Epub 2009 Jan 30.

Current thoughts on the role of mitochondria and free radicals in the biology of aging

Holly Van Remmen  1 , Dean P Jones
Affiliations
Review

Current thoughts on the role of mitochondria and free radicals in the biology of aging

Holly Van Remmen et al. J Gerontol A Biol Sci Med Sci. 2009 Feb.
No abstract available

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References

    1. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298–300. - PubMed
    1. Van Remmen H, Ikeno Y, Hamilton M, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics. 2003;16:29–37. - PubMed
    1. Huang TT, Carlson EJ, Gillespie AM, Shi Y, Epstein CJ. Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci. 2000;55(1):B5–B9. - PubMed
    1. Jang Y, Perez V, Song W. Overexpression of Mn superoxide dismutase protects against oxidative stress but does not increase lifespan in mice. J Gerontol A Biol Sci Med Sci. In Review. - PMC - PubMed
    1. Perez V, Van Remmen H, Bokov A, Epstein CJ, Vijg J, Richardson A. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell. In Press. - PMC - PubMed

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