Effect of zinc on growth of preterm babies

Abstract

Zinc is being recognized increasingly as an important element in human growth, development and immunological function. It is probably the most intensely studied microelement in newborn nutrition. Zinc deficiency is common in young infants in the developing world and is associated with reduced immunocompetence and increased rates of serious disease. Preterm neonates are especially vulnerable because of preterm delivery and low birth weight. The preterm baby has very limited stored energy and needs an adequate supply of nutrient. Preterm infant have high zinc dietary requirements as 60% fetal zinc is acquired during third trimester of pregnancy. Low concentration of zinc was found in pre-term low birth weight babies in different studies. Studies showed that before supplementation serum zinc level in preterm low birth weight babies were 62+/-12.4 microgm/dl, 65 microgm/dl, 54+/-14.4 microgm/dl and after supplementation serum zinc level were 105.8+/-16.6 microgm/dl, 86.4+/-24.7 microgm/dl respectively. At the same time mean weight & length of supplementation and without supplementation group were 6084 gm vs. 5280 gm, 2779+/-638.7 gm vs. 2474.6+/-441.8 gm and length 23.7 cm vs. 21.4 cm, 46.49+/-2.6 cm vs. 44.1+/-2.8 cm respectively. So supplementation of zinc in preterm babies causes improved growth and development. Various reports showed beneficial effect of long supplement in early growth of pre-term babies. However long term follow up studies are needed to evaluate the beneficial effect of zinc supplementation on growth of preterm babies.