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Clinical Trial
. 2008;4(5):1089-94.
doi: 10.2147/vhrm.s2928.

Frequency of secondary dyslipidemia in obese children

Ulrike Korsten-Reck  1 , Katrin Kromeyer-Hauschild, Katrin Korsten, Manfred W Baumstark, Hans-H Dickhuth, Aloys Berg
Affiliations
Clinical Trial

Frequency of secondary dyslipidemia in obese children

Ulrike Korsten-Reck et al. Vasc Health Risk Manag. 2008.

Abstract

Objective: This paper reports the frequency, type, and degree of dyslipidemia in obese children before therapeutic intervention. The relationships between lipid values and weight status, as well as lipid values and physical fitness, of these children were also investigated.

Design and methods: The initial examination of the Freiburg Intervention Trial for Obese Children (FITOC) measured the values of triglycerides (TG), total cholesterol (C), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in 546 obese children aged 7-12 (body mass index [BMI] > 97th percentile), and compared these values with those of the age- and sex-specific reference group in the Lipid Research Clinics Population Studies Data Book (LRC). Four groups were selected according to the following scheme: A, Normolipidemia; B, Hyper-LDL-cholesterolemia alone; C, Hypo-HDL-C + hypertriglyceridemia; D, Combined hyperlipidemia = Hyper-LDL-C + hypertriglyceridemia. Body mass index, BMI-SDS (corrected BMI), and physical performance in watt/kg body weight were measured.

Results: A total of 45.8% of the overweight children showed an abnormal lipid profile. Ten percent of the children had high LDL-C levels (group B), while 15% had increased LDL-C and increased TG (group D) (higher prevalence in boys). In 18.9% we found increased TG, combined with decreased HDL-C values (group C).

Conclusion: Obese children are at risk of dyslipoproteinemia and related diseases. Children with the highest BMI-SDS and lowest physical fitness have the lowest HDL-C values and increased TG, indicating a higher risk for the metabolic syndrome.

Keywords: atherosclerotic risk; childhood; dyslipidemia; obesity.

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Figures

Figure 1
Figure 1
Distribution of the individual LDL-C of FITOC Children compared with the LRC Study. Abbreviations: FITOC, freiburg intervention trial for obese children; LDL-C, low-density lipoprotein cholesterol; LRC, lipid research clinics population studies data book.
See this image and copyright information in PMC

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