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. 1977 Mar;74(3):897-901.
doi: 10.1073/pnas.74.3.897.

Granulocyte collagenase: selective digestion of type I relative to type III collagen

A L Horwitz, A J Hance, R G Crystal

Granulocyte collagenase: selective digestion of type I relative to type III collagen

A L Horwitz et al. Proc Natl Acad Sci U S A. 1977 Mar.

Abstract

Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.

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