Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Apr;47(3-4):295-300.
doi: 10.1007/s10528-009-9228-4. Epub 2009 Jan 31.

Melanocortin-4 receptor gene polymorphisms in obese patients

Erkan Yurtcu  1 , Akin Yilmaz, Zubeyde Ozkurt, Emine Kolukisa, Murat Yilmaz, Hatice Keles, Mehmet Ali Ergun, Ilhan Yetkin, Adnan Menevse
Affiliations

Melanocortin-4 receptor gene polymorphisms in obese patients

Erkan Yurtcu et al. Biochem Genet. 2009 Apr.

Abstract

Obesity is a complex disease caused by both genetics and environmental factors. Melanocortin-4 receptor (MC4R) (MIM 155541) gene polymorphisms were reported to be the cause of monogenic obesity in humans. We studied three polymorphisms (Val50Met, Val103Ile, and Ser58Cys) and a mutation (Asn274Ser) of the MC4R gene in 203 obese patients and in 110 healthy subjects in the Turkish population. A high incidence of Val103Ile and Val50Met polymorphisms as well as the Asn274Ser mutation was found in the obese patients, whereas no significant correlation was found regarding the Ser58Cys polymorphism. We conclude that there is a concordance between the polymorphisms (Val103Ile, Val50Met, Ser58Cys) that were first studied in the Turkish population with obesity.

PubMed Disclaimer

Substances

Associated data