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. 2009;48(11):1896-8.
doi: 10.1002/anie.200805604.

Asymmetric hydroboration of 1,1-disubstituted alkenes

Stephen P Thomas  1 , Varinder K Aggarwal
Affiliations

Asymmetric hydroboration of 1,1-disubstituted alkenes

Stephen P Thomas et al. Angew Chem Int Ed Engl. 2009.

Abstract

A breakthrough in the asymmetric hydroboration of notoriously difficult 1,1-disubstituted alkenes using a new family of highly effective hydroboration reagents is described (see scheme). The intermediate boranes can be oxidized to alcohols or used in Suzuki-Miyaura cross-coupling reactions.

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