Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Feb;157(2):319-26.
doi: 10.1016/j.ahj.2008.10.005. Epub 2008 Dec 17.

Rationale and design of the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)

Kim A Eagle  1 ; GenTAC Consortium
Collaborators, Affiliations

Rationale and design of the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)

Kim A Eagle et al. Am Heart J. 2009 Feb.

Abstract

Background: Although the management of thoracic aortic aneurysms (TAAs) has improved significantly, patients presenting with aortic dissections, rupture, or other acute complications of TAAs continue to have high rates of morbidity and mortality. Accumulating data have indicated that many TAAs are due to underlying gene mutations. A comprehensive approach to the study of TAAs resulting from genetic mutations is needed to translate this information into advances in treatment.

Objective: The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was established to provide a biospecimen inventory and bioinformatics infrastructure to enable research to advance the clinical management of genetically triggered TAAs and related complications.

Methods: GenTAC is a longitudinal observational cohort study enrolling patients with conditions related to genetically induced TAAs from 5 regional clinical centers in the United States.

Results: More than 700 subjects with associated clinical histories, physical examinations, imaging data, and biospecimens have been enrolled in the Registry to date. Enrollment is expected to continue until September 2010. Total enrollment of nearly 3,000 subjects is expected. No interim analysis has yet been undertaken.

Conclusions: GenTAC has been established to facilitate studies by GenTAC investigators and others that will advance multiple scientific frontiers in thoracic aortic disease. Genotypic, proteomic, clinical, and imaging data will be integrated systematically with outcomes data to determine the optimal clinical management of patients with genetically induced TAAs.

PubMed Disclaimer

Figures

Figure I
Figure I
GenTAC Project Organization chart.
Figure II
Figure II
GenTAC Regional Centers and a number of the states they will serve as the registry enrolls patients.
See this image and copyright information in PMC

References

    1. United States Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, Office of analysis, Epidemiology and Health Promotion (2005) Compressed mortality file (CM) compiled from CMF 1999–2001, Series 20, No. 2G 2004 on CDC WONDER. [accessed 2/23/2005]. Online database, http://wonder.cdc.gov.
    1. Roman MJ, Devereux RB, Niles NW, et al. Aortic root dilatation as a cause of isolated, severe aortic regurgitation. Prevalence, clinical and echocardiographic patterns, and relation to left ventricular hypertrophy and function. Ann Intern Med. 1987;106:800–807. - PubMed
    1. Silverman DI, Burton KJ, Gray J, Bosner MS, Kouchoukos NT, Roman MJ, Boxer M, Devereux RB, Tsipouras P. Life expectancy in the Marfan syndrome. Am J Cardiol. 1995;75:157–160. - PubMed
    1. Gott VL, Cameron DE, Alejo DE, Greene PS, Shake JG, Caparrelli DJ, Dietz HC. Aortic root replacement in 271 Marfan patients: a 24-year experience. Ann Thorac Surg. 2002;73:438–443. - PubMed
    1. Clouse WD, Hallett JW, Jr, Schaff HV, Spittell PC, Rowland CM, Ilstrup DM, Melton LJ., 3rd Acute aortic dissection: population-based incidence compared with degenerative aortic aneurysm rupture. Mayo Clin Proc. 2004;79:176–180. - PubMed

Publication types