True osseous metaplasia of the endometrium: the bone is not from a fetus

Abstract

Objective: To identify the origin of calcified tissue in endometrial ossification.

Design: DNA analyses from the ossified tissue and from the woman were studied to compare both genotypes.

Setting: University and general hospitals.

Patient(s): A 27-year-old infertile woman diagnosed of osseous metaplasia of the endometrium.

Intervention(s): Hysteroscopic resection of the endometrial osseous metaplasia for DNA analysis.

Main outcome measure(s): DNA comparison between the patient and the osseous tissue extracted from the uterus.

Result(s): All markers produced the same allele length for both blood and endometrial biopsy (including bones), thus confirming the same genetic origin.

Conclusion(s): Endometrial ossification is derived from the patient, resulting in a true osseous metaplasia.