Glia, adenosine, and sleep
- PMID: 19186158
- DOI: 10.1016/j.neuron.2009.01.005
Glia, adenosine, and sleep
Abstract
Sleep is regulated by a homeostatic process that has long been thought to involve adenosine (AD) originating from neurons. In this issue of Neuron, Halassa et al. present evidence that sleep homeostasis depends upon gliotransmission and associated accumulation of AD that dampens neuronal excitability.
Comment on
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Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.Neuron. 2009 Jan 29;61(2):213-9. doi: 10.1016/j.neuron.2008.11.024. Neuron. 2009. PMID: 19186164 Free PMC article.
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